Silence Therapeutics Plc (SLN US)
SLN US$19.71
20 minute delayed
14 days free access
Join Market Matters and get full access to all our Opinion + Action
Performance
Share price activity
- Last (Price)
- 19.71
- Change
- ▼ -0.08 (-0.38)
- Bid / Ask
- 19.70 - 19.72
- Volume
- 221,212
- Turnover
- 4,155,863
- Open
- 19.76
- Day Range
- 19.70 - 19.79
- VWAP
- 19.74
- Prev Close
- 19.78
- Last Trade
- 28/10 3:59pm
Key information
- Sector
- Healthcare
- Shares Issued
- 60,209,356
- NTA/Share
- 1.09
- Last Dividend
- —
- Dividend Ex Date
- —
- Dividend Pay Date
- —
Current (USD) · FY2025
- Revenue
- 0.56
- EBITDA
- -91.53
- Profit
- -88.61
- Earnings Per Share (EPS)
- -1.89
- Dividend Per Share (DPS)
- —
- Yield %
- 0.00
- Market Cap
- 1,225.71
- Price to Earnings Ratio (P/E)
- -15.28
Estimates (GBP) · FY2027
- Revenue
- 0.00
- EBITDA
- -74.83
- Profit
- -70.23
- Earnings Per Share (EPS)
- -1.04
- Dividend Per Share (DPS)
- —
Quantitative rating
Overvalued
- Economic Moat
- None
- Financial Health
- Moderate
- Uncertainty
- Very High
Morningstar Quantitative Rating as of 23 OCT 2026.
Quantitative Equity Rating Methodology – view here
Fair value estimate
Five-star price 7.11 Fair value 14.77 One-star price 30.69
Morningstar Quantitative Rating as of 23 OCT 2026.
Quantitative valuation
- Fair Value
- 14.77
- Price / Fair Value
- 1.33
- Valuation
- Overvalued
- Uncertainty
- Very High
Morningstar Quantitative Rating as of 23 OCT 2026. The slider runs from the five-star price (7.11) to the one-star price (30.69).
| Ratios |
|---|
| Currency (Price/reporting): USD/USD |
| Exchange Rate: 1.0000 |
| Price - closing or last bid | 19.66 |
| Price - 12 month high | 19.68 |
| Price - 12 month low | 4.20 |
| Pricing date | 22 OCT 2026 |
| Volume - avg. trading volume for the last ten days | 9.15 |
| Market capitalization | 1,223.53 |
| 12 Month High price date | 22 OCT 2026 |
| 12 Month Low price date | 12 FEB 2026 |
| Volume - avg. trading volume for the last 3 months | 2.56 |
| Price - 1 Day % Change | 0.00% |
| Price - 13 week price percent change | 71.70% |
| Price - 26 week price percent change | 150.77% |
| Price - 5 Day % Change | 126.50% |
| Price - 52 week price percent change | 171.17% |
| Price - YTD price percent change | 219.67% |
| Price % Change Month To Date | 70.81% |
| EPS excluding extraordinary items - most recent fiscal year | -1.890 |
| EPS excluding extraordinary items - trailing 12 month | -1.290 |
| EPS Normalized - most recent fiscal year | -1.566 |
| Revenue/share - most recent fiscal year | 0.012 |
| Revenue/share - trailing 12 month | 0.013 |
| Book value per share - most recent fiscal year | 1.319 |
| Book value per share - most recent quarter | 0.814 |
| Book value (tangible) per share - most recent fiscal year | 1.088 |
| Book value (tangible) per share - most recent quarter | 0.591 |
| Cash per share - most recent fiscal year | 0.239 |
| Cash per share - most recent quarter | 1.525 |
| Cash Flow per share - most recent fiscal year | -1.534 |
| Cash Flow per share - trailing 12 month | -1.197 |
| Dividend per share - most recent fiscal year | — |
| Dividends per share - trailing 12 month | 0.000 |
| EBITD per share - trailing 12 month | -1.259 |
| EPS Basic excluding extraordinary items - most recent fiscal year | -1.890 |
| EPS Basic excluding extraordinary items - trailing 12 month | -1.290 |
| EPS including extraordinary items - most recent fiscal year | -1.890 |
| EPS including extraordinary items - trailing 12 month | -1.290 |
| Free Cash Flow per share - trailing 12 month | -1.197 |
| P/E excluding extraordinary items, most recent fiscal year | — |
| P/E Normalized, most recent fiscal year | — |
| Price to sales - most recent fiscal year | 1,510.75 |
| Price to Tangible Book - most fiscal year | 33.30 |
| Price to Free Cash Flow per Share - most recent fiscal year | — |
| Price to Cash Flow per share - trailing 12 month | — |
| Price to Book - most recent fiscal year | 24.16 |
| P/E excluding extraordinary items high, trailing 12 months | — |
| P/E excluding extraordinary items low, trailing 12 months | — |
| Net Debt, LFI | -71.94 |
| Net Debt, LFY | -84.95 |
| Dividend Yield - 5 Year Average | — |
| Dividend Yield - indicated annual dividend divided by closing price | — |
| Current Dividend Yield - Common Stock Primary Issue, LTM | 0.00% |
| Free Cash Flow - most recent fiscal year | -72.49 |
| LT debt/equity - most recent fiscal year | 0.11% |
| Payout ratio - most recent fiscal year | — |
| Total debt/total equity - most recent fiscal year | 0.26% |
| LT debt/equity - most recent quarter | 0.02% |
| Total debt/total equity - most recent quarter | 0.29% |
| Free Cash Flow - trailing 12 month | -56.56 |
| Payout ratio - trailing 12 month | — |
| Revenue - most recent fiscal year | 0.56 |
| Revenue - trailing 12 month | 0.62 |
| EBITD - most recent fiscal year | -91.53 |
| EBITD - trailing 12 month | -59.47 |
| Earnings before taxes - most recent fiscal year | -88.60 |
| Earnings before taxes - trailing 12 month | -59.95 |
| Net Income available to common - most recent fiscal year | -88.61 |
| Net Income available to common - trailing 12 months | -59.95 |
| Earnings before taxes Normalized - most recent fiscal year | -68.18 |
| Net Income Available to Common, Normalized - most recent fiscal year | — |
| Earnings per Share, Normalized, Excluding Extraordinary Items, Avg. Diluted Shares Outstanding, TTM | -1.20 |
| Net Profit Margin % - 1st historical fiscal year | -15,851.88% |
| Net Profit Margin % - trailing 12 month | -9,748.46% |
| Operating margin - 1st historical fiscal year | -16,055.99% |
| Operating margin - trailing 12 month | -11,106.83% |
| Pretax margin - trailing 12 month | -9,748.13% |
| Pretax margin - 1st historical fiscal year | -15,849.91% |
| Operating Margin - 5 year average | -3,411.35% |
| Pretax Margin - 5 year average | -3,343.93% |
| Free Operating Cash Flow/Revenue, 5 Year Average | -1,631.73% |
| Free Operating Cash Flow/Revenue, TTM | -9,195.94% |
| Net Profit Margin - 5 year average | -3,335.57% |
| Return on average assets - most recent fiscal year | -53.29% |
| Return on average assets - trailing 12 month | -45.08% |
| Return on average equity - most recent fiscal year | -175.96% |
| Return on average equity - trailing 12 month | -94.15% |
| Return on average assets - 5 year average | -40.10% |
| Return on average equity - 5 year average | -311.83% |
| Net Income/employee - most recent fiscal year | -1,006,954.55 |
| Revenue/employee - most recent fiscal year | 6,352.27 |
| Revenue growth rate, 5 year | -39.72% |
| EPS growth rate, 5 year | — |
| Growth rate% - dividend, 3 year | — |
| Revenue/share (5 yr growth) | -46.00% |
| Growth rate% - Revenue, 3 year | -70.45% |
| Growth rate% - EPS, 3 year | — |
| Book value per share growth rate, 5 year | 51.71% |
| Capital Spending growth rate, 5 year | -39.14% |
| Earnings Before Interest, Taxes, Depreciation & Amortization, 5 Year CAGR | — |
Financial forecast (GBP, millions except per share)
| Actuals | Estimates | |||||||
| 2025 | 2026 | 2027 | 2028 | 2029 | ||||
| Estimate breakdown | ||||||||
Financials (USD, millions)
| Period end: | DEC 21 | DEC 22 | DEC 23 | DEC 24 | DEC 25 |
| Fiscal year: | 2021 | 2022 | 2023 | 2024 | 2025 |
| Period length: | 12 months | 12 months | 12 months | 12 months | 12 months |
Announcements
Announcements are available for ASX-listed companies only.
Opinion
No opinions for this company yet.
Action
No actions for this company yet.
Business Summary
Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid or siRNA. Using its mRNAi GOLD platform, the company has generated siRNA product candidates both for its internal development pipeline as well as for out-licensed programs with third-party collaborators. Its wholly owned pipeline is focused on three therapeutic areas: cardiovascular disease, hematology, and rare diseases. The different product candidates in its pipeline are Divesiran (SLN124), a siRNA product candidate that has the potential to treat several hematological disorders; Zerlasiran (SLN360), being developed as a potential treatment to reduce cardiovascular issues; SLN-312; SLN-548; and multiple other programs.